« それ何語カマラード | Main | それ何語マネージ »
「あしたまにあ～な」、元は"hasta mañana（アスタ マニャーナ）"から来ているのです。たぶん。
映画「ターミネーター」でも出てきた"hasta la vista, baby"。
"Até breve,obrigado（アテ ブレーベ、オブリガード）"。
「また明日」って言うと"ate amanhã（アテ アマニャン）"になります。
作成開始：07-20-2004 at 12:58 AM
作成終了：07-20-2004 at 01:32 AM
Posted by 葉 on July 20, 2004 at 08:30 PM | Permalink
« それ何語カマラード | Main | それ何語マネージ »
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Author: John Suchocki, Instructor
Affiliation: St. Michael’s College, Colchester, VT
Article Word Count: 800
Discussion Questions: 5
Date Posted: June, 2010
Living isn’t easy, especially at the level of the molecules that make us. Our cells and the molecules they contain are constantly exposed to a hostile environment of viruses, bacteria, free radicals, radiation, and random chemical reactions. We live because our bodies are able to repair themselves from perpetual molecular damage. Over time, however, our bodies lose the ability to self-heal. We age. We grow frail and eventually die.
Since the introduction of modern medicine and better health habits, the average life expectancy of humans has increased dramatically—in the United States from about 48 years old in 1900 to about 78 years old in 2000. The maximum attainable human life span of about 120 years, however, appears to have remained fairly constant. Is there truly a limit to how old we can live? Is it possible to change how long we live while still maintaining a youthful vigor and resilience? After all, the quality of life matters just as much if not more so than the quantity of life.
Scientists have long known that a healthier and longer life can be attained by reducing the intake of calories by at least one-third of a normal healthy diet while maintaining necessary nutrients. Worms fed such a calorie-restricted diet live up to 5 months longer, which for them is a life span increase of about 60%. Mice live about 14 months longer (50% increase) and dogs also about 14 months longer (10% increase). Would calorie restriction also help humans extend their maximum life span? The answer is likely yes, but by how much is questionable. Some scientists are optimistic that it could add 10 to 15 years. Others are more cautious in thinking maybe 2 to 3 years is more reasonable. Either way, there are potential benefits to be had and every gain counts.
Scientists are working to unravel the molecular mysteries of why calorie restriction works. This, in turn, should help them to discover compounds that mimic the effects of calorie restriction. Interestingly, one class of compounds that mimics the effects are polyphenols , which are abundant in highly pigmented foods, such as pomegranates, or beverages, such as red wine.
Gerontologists who study the aging process have come to recognize at least six categories of damage sustained by our cells and biomolecules (See Table). These would be the underlying causes of our becoming frail and more susceptible to death as we grow older. Prevent or reverse these damages and the result would be a rejuvenated body, which, in turn, would have a greater chance of experiencing an extended life span. The important thing to note here is that we’re not talking about keeping old people alive in their frailty. Instead, we’re talking about strategies that would permit people to both look and feel better despite having lived for so many years. Humans would remain productive and active for much longer periods of time.
Problem Current and Potential Remedies
Cells die and are not replaced.
Improved health habits; Growth factors; Gene doping , Stem cells; Apoptosis active dephosphorylation inhibitors (salubrinal ).
DNA within the cell nucleus is altered giving rise to cancer.
Improved health habits; Chemotherapy; Radiation therapy; Surgery; Telomere restoration therapy ; Gene therapy; Nanoshells .
DNA within cellular mitochondria is altered resulting in cell death.
Gene therapy to produce mitochondrial proteins from nuclear DNA.
Unwanted cells, such as fat cells, accumulate.
Improved health habits; Calorie restriction diet ; Surgery; Target cell surface differences.
Collagen loses elasticity because of cross-linking.
Sun screen; Advanced Glycosylation Endproduct breaker drugs, such as ALT-711 , to break cross-links or inhibit their formation.
Accumulation of unwanted junk such as atherosclerotic and amyloid plaques.
Beta sheet breaker peptides ; Inhibition of ABAD beta amyloid complex ; Genetically modified white blood cells; Lysosome replacement therapy .
Do you suppose scientists are interested in finding remedies to the problems listed in the Table? How interested? How about the businesses or organizations that sponsor the scientists? Do you suppose more or less money will be channeled into these efforts as more promising discoveries are made? Might the demand be greater than anything ever known to human-kind? Will there be a sufficient demand for resulting products that provide for a longer and healthier life? With wrinkle-free skin? Will people of impoverished nations be able to afford this anti-aging technology? Should it be offered freely? Might we have more or fewer remedies available to us by the time you are 40 years older? Might these remedies allow you to live another 40 years? Might there be even more remedies available after your extra 40 years of healthy living? What if medical science advances faster than you age? Do you understand that we don’t presently need to know how to help you reach your 1000 th birthday in order for you to reach your 1000 th birthday, or beyond?
How are people like cars?
Was This Your Answer?
Leonard Hayflick of the University of California at San Francisco, says people are like cars because they age reliably “even though there’s nothing in the blueprints that shows a process for doing it.” In other words, there is no “death gene,” no mechanism that kills us off after a certain time limit; aging is a consequence of living in a corrosive environment. If, however, you want to keep a car like “new”, what do you do? Wait until it’s ready to fall apart? Or repair as necessary despite the expense of new body parts or skilled labor? Both people and cars need daily maintenance if their life expectancies are to be maximized. If a car can be nurtured to live for many centuries, can people too? Do we have the resources?
Think and Discuss:
1. There are millions of people who don’t exercise or eat right even though they know such habits will likely extend how long they live in good health. Why?
2. In the past 20 years, the average life expectancy within most nations has risen by a couple years, but so has the “healthy life expectancy”, which is a measure of how long people remain in good health. Are the two necessarily related? How so?
3. What effects might a cure for aging have on the problem of overpopulation?
4. How would society be able to support so many people living well into their 100’s?
5. The Pentagon today owes its soldiers $653 billion in future retirement benefits. What might happen to this cost if the soldiers actually lived some 40 years longer than expected? How about 100 years? 500 years? At what point should the pentagon no longer “owe” these benefits to the soldiers? What trends do you foresee in company retirement plans? Might there be a greater emphasis on “privatized retirement accounts”? Why?
Comments # Questions 1 — Administrator 2010-06-10 19:27 1. There are millions of people who don’t exercise or eat right even though they know such habits will likely extend how long they live in good health. Why? Reply # Questions 2 — Administrator 2010-06-10 19:27 2. In the past 20 years, the average life expectancy within most nations has risen by a couple years, but so has the “healthy life expectancy”, which is a measure of how long people remain in good health. Are the two necessarily related? How so? Reply # Question 3 — Administrator 2010-06-10 19:28 3. What effects might a cure for aging have on the problem of overpopulation? Reply # Question 4 — Administrator 2010-06-10 19:28 4. How would society be able to support so many people living well into their 100’s? Reply # Question 5 — Administrator 2010-06-10 19:29 5. The Pentagon today owes its soldiers $653 billion in future retirement benefits. What might happen to this cost if the soldiers actually lived some 40 years longer than expected? How about 100 years? 500 years? At what point should the pentagon no longer “owe” these benefits to the soldiers? What trends do you foresee in company retirement plans? Might there be a greater emphasis on “privatized retirement accounts”? Why? Reply # Extending Human Life Span — Victorina 2014-03-22 01:59 Hello my family member! I wish to say that this post is awesome, great written and include almost all significant infos.